DRUGS THAT CAN PROMOTE WEIGHT GAIN

  • Antipsychotics, especially olanzepine (Zyprexa)
  • Antidepressants: tricyclics, SSRIs, MAOIs, mirtazepine (Zispin) and lithium
  • Corticosteroids: promote weight gain by two mechanisms, (i) Fat redistribution causing truncal obesity, buffalo hump and moon face; and (ii) fluid retention via mineralocorticoid effects
  • Oral contraceptive and progesterogenic compounds
  • Beta-blockers: not only do these agents cause weight gain, they might also restrict physical activity due to fatigue
  • Oral hypoglycaemics: numerous agents have been shown to increase weight, including the glitazones. Sulphonylureas (except glimepiride) have been shown to increase weight by an average of 2-4 kg but by as much as 10 kg in some cases
  • Insulin
  • Anticonvulsants: weight gain has been documented with some agents (phenytoin, sodium valproate). However, topiramate (Topamax) is weight neutral or may cause weight loss
  • Antihistamines: many antihistamines might cause weight gain, although this is more pronounced in older agents
  • Pizotifen: a prophylactic migraine treatment, pizotifen increases the appetite and leads to weight gain

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WEIGHT LOSS/BODY-BUILDING